In this context, exercise has been pointed out as an interesting strategy promoting several benefits in the elderly individuals. Nowadays, it is observed increased research on both pharmacological and non-pharmacological tools to prevent and minimize the physiological age modifications and diseases. HATs produce a larger chromatin structure, characteristic that allows transcriptional activation, whereas HDACs exert the opposite effect.
Histone acetylation status is regulated by histone acetyl transferees (HATs) and histone deacetylases (HDACs). ĭNA methylation is a process catalyzed by DNA methyl transferees (DNMTs) enzymes and is usually associated with transcriptional repression and gene silencing. The hallmarks of epigenetic gene regulation include DNA methylation and histone acetylation levels modifications. Epigenetic process result in heritable phenotypical alterations in the expression of specific genes without alter the primary DNA sequence. Emerging experimental and clinical evidences suggest that the imbalance of epigenetic machinery plays a pivotal role in both normal aging process as well in age-related diseases. To clarify specific mechanisms of the biological aging process and the elaboration of combined strategies for the management of elderly health are urgent in order to guarantee the quality of life of this population. Keywords: Exercise Running Aging Epigenetic Inflammation Īging has become increasingly in the world population and the projection for 2050 is that people over 60 years old be around 2 billion. Furthermore, the inflammatory response may indicate a possible regulatory effect provided by the endurance exercise in the elderly group because IL-4 and IL-6 are synergic cytokines directing an immune response. The IL-6 and IL-4 levels were significantly higher in the EXE group after the running performance compared to the before running period (p=0,004 and 0,013 respectively), while DNA methylation status remained unaltered.Ĭonclusion: Our data suggest that DNA methylation status might not be consider a potential biomarker related to the healthy elderly runners phenotype. However, the SED group showed increased IL-4 and IL-6 levels when compared to the RUN individuals (p= 0,040 and 0,035, respectively). Results: FIn the basal period, no significant differences were observed on DNA global methylation status between the SED and RUN groups. After 5 days, two blood samples were collected in the RUN group: 30 min before and immediately after a 5-10km outdoor running performance.The blood samples (15mL) were collected for the epigenetic and inflammatory measurements, which were done using specific kits, according to the manufacturer’s instructions. All participants, SED and RUN groups, were submitted to a basal blood collection. They were allocated in two groups: runners (RUN, n=8) and sedentary (SED, n=7), considering if they were sedentary or amateur street runners. Methods: Fifteen male volunteers aged 60 years and older were recruited. Objectives: The current study aimed to evaluate 1) the impact of the regular running practice 2) as well the acute effect of running race on inflammatory markers and DNA methylation status in peripheral blood of health elderly men.
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